Phenotypes associated with this allele

• Allele Symbol: Selenos^tm1.1Sfa
• Allele Name: targeted mutation 1.1, Sofianos Andrikopoulos
• Allele ID: MGI:6257874
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Selenos^tm1.1Sfa/Selenos^tm1.1Sfa	involves: C57BL/6	MGI:6258428
ht2	Selenos^tm1.1Sfa/Selenos^+	involves: C57BL/6	MGI:6258429
cx3	Dmd^mdx/Dmd^mdx Selenos^tm1.1Sfa/Selenos^+	involves: C57BL/6 * C57BL/10ScSn	MGI:6258417

Genotype
MGI:6258428

hm1

• Allelic Composition: Selenos^tm1.1Sfa/Selenos^tm1.1Sfa
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased locomotor activity ( J:264254 )

• over a 24 hour period

growth/size/body

growth/size/body region phenotype ( J:264254 )

N • mice exhibit normal body weight and composition including normal fat mass and lean mass

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:264254 )

N • mice exhibit normal resting energy expenditure

muscle

muscle phenotype ( J:264254 )

N • mice exhibit normal extensor digitalis longus and soleus muscle structure

muscle weakness ( J:264254 )

• reduced force at submaximal stimulation frequencies

• reduced force during intermittent, submaximal stimulation

• reduced tolerance to high-frequency contractions in fast-twitch EDL muscles

• however, mice exhibit a normal response to 60-Hz stimulation of the force frequency curve and the first 60-Hz stimulation of the fatigue protocol

Genotype
MGI:6258429

ht2

• Allelic Composition: Selenos^tm1.1Sfa/Selenos⁺
• Genetic Background: involves: C57BL/6

muscle

muscle phenotype ( J:264254 )

N • mice exhibit normal extensor digitalis longus and soleus muscle structure

muscle weakness ( J:264254 )

• reduced force during intermittent, submaximal stimulation

• reduced tolerance to high-frequency contractions in fast-twitch EDL muscles

behavior/neurological

decreased locomotor activity ( J:264254 )

• over a 24 hour period

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:264254 )

N • mice exhibit normal resting energy expenditure

Genotype
MGI:6258417

cx3

• Allelic Composition: Dmd^mdx/Dmd^mdx; Selenos^tm1.1Sfa/Selenos⁺
• Genetic Background: involves: C57BL/6 * C57BL/10ScSn

homeostasis/metabolism

increased carbon dioxide production ( J:266872 )

• compared with Dmd^mdx homozygotes during the first two active hours at night

increased oxygen consumption ( J:266872 )

• compared with Dmd^mdx homozygotes during the first two active hours at night

abnormal respiratory quotient ( J:266872 )

• elevated as in Dmd^mdx homozygotes relative to wild-type mice

growth/size/body

decreased body mass index ( J:266872 )

• between 6 and 12 weeks compared with Dmd^mdx homozygotes

decreased lean body mass ( J:266872 )

• between 6 and 12 weeks compared with Dmd^mdx homozygotes

muscle

muscle phenotype ( J:266872 )

N • extensor digitalis longus and soleus muscles wet weight is normal

abnormal skeletal muscle fiber type ratio ( J:266872 )

• increased number of small fibres and fewer large fibres than in Dmd^mdx homozygotes

• however, there was no difference in the number of central nuclei suggesting normal regeneration