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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mlf1tm1Swm
targeted mutation 1, Stephan W Morris
MGI:6257884
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mlf1tm1Swm/Mlf1tm1Swm involves: 129 * C57BL/6 MGI:6267419
cx2
 		Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Mlf1tm1Swm/Mlf1tm1Swm 		involves: 129S1/Sv * C57BL/6 MGI:6267420


Genotype
MGI:6267419
hm1
Allelic
Composition		 Mlf1tm1Swm/Mlf1tm1Swm
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlf1tm1Swm mutation (0 available); any Mlf1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased splenocyte apoptosis ( J:266833 )
• of splenic B and T cells ex vivo upon cytokine depletion
• in response to cis-diammine-dichloroplatinum II (cisplatin), phorbol 12- myristate 13-acetate (PMA), dexamethasone (Dex), anti-Fas, and UV irradiation
• however, response to gamma-irradiation is normal
increased B cell number ( J:266833 )
• slight in the spleen
• however, splenic T cell and thymocyte numbers are normal

cellular
decreased splenocyte apoptosis ( J:266833 )
• of splenic B and T cells ex vivo upon cytokine depletion
• in response to cis-diammine-dichloroplatinum II (cisplatin), phorbol 12- myristate 13-acetate (PMA), dexamethasone (Dex), anti-Fas, and UV irradiation
• however, response to gamma-irradiation is normal

hematopoietic system
decreased splenocyte apoptosis ( J:266833 )
• of splenic B and T cells ex vivo upon cytokine depletion
• in response to cis-diammine-dichloroplatinum II (cisplatin), phorbol 12- myristate 13-acetate (PMA), dexamethasone (Dex), anti-Fas, and UV irradiation
• however, response to gamma-irradiation is normal
increased B cell number ( J:266833 )
• slight in the spleen
• however, splenic T cell and thymocyte numbers are normal




Genotype
MGI:6267420
cx2
Allelic
Composition		 Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Mlf1tm1Swm/Mlf1tm1Swm
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Ast mutation (4 available); any Bcl2l11 mutation (36 available)
Mlf1tm1Swm mutation (0 available); any Mlf1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased thymocyte apoptosis ( J:266833 )
• ex vivo upon cytokine depletion compared with wild-type and Bcl2l11tm1.1Ast homozygous cells
decreased splenocyte apoptosis ( J:266833 )
• almost no loss of cellular viability ex vivo upon cytokine depletion compared with wild-type and Bcl2l11tm1.1Ast homozygous cells

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:266833 )
• ex vivo upon cytokine depletion compared with wild-type and Bcl2l11tm1.1Ast homozygous cells

hematopoietic system
decreased thymocyte apoptosis ( J:266833 )
• ex vivo upon cytokine depletion compared with wild-type and Bcl2l11tm1.1Ast homozygous cells
decreased splenocyte apoptosis ( J:266833 )
• almost no loss of cellular viability ex vivo upon cytokine depletion compared with wild-type and Bcl2l11tm1.1Ast homozygous cells

immune system
decreased thymocyte apoptosis ( J:266833 )
• ex vivo upon cytokine depletion compared with wild-type and Bcl2l11tm1.1Ast homozygous cells
decreased splenocyte apoptosis ( J:266833 )
• almost no loss of cellular viability ex vivo upon cytokine depletion compared with wild-type and Bcl2l11tm1.1Ast homozygous cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory