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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(KRT5-Terf2)PNBlas
transgene insertion PN, Maria A Blasco
MGI:6258223
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(KRT5-Terf2)PNBlas/0 involves: C57BL/6 * CBA MGI:6258419


Genotype
MGI:6258419
tg1
Allelic
Composition
Tg(KRT5-Terf2)PNBlas/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice are born with normal Mendelian distribution, unlike Tg(KRT5-Terf2)PMBlas transgenic males

pigmentation
• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
• mice exhibit mild hyperpigmentation of light-exposed skin areas (tail, paws and ear) relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice

integument
• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
• mice exhibit mild hyperpigmentation of light-exposed skin areas (tail, paws and ear) relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice

cellular
• at 4 months of age, mice exhibit markedly shorter telomeres in tail skin than age-matched wild-type controls

neoplasm
N
• older mice do NOT develop spontaneous tumors in light-exposed areas of the skin, such as the tail

craniofacial
• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice

growth/size/body
• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice

hearing/vestibular/ear
• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice

limbs/digits/tail
• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory