mortality/aging
N |
• mice are born with normal Mendelian distribution, unlike Tg(KRT5-Terf2)PMBlas transgenic males
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pigmentation
• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
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• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
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• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
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• mice exhibit mild hyperpigmentation of light-exposed skin areas (tail, paws and ear) relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
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integument
• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
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• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
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• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
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• mice exhibit mild hyperpigmentation of light-exposed skin areas (tail, paws and ear) relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
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cellular
• at 4 months of age, mice exhibit markedly shorter telomeres in tail skin than age-matched wild-type controls
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neoplasm
N |
• older mice do NOT develop spontaneous tumors in light-exposed areas of the skin, such as the tail
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craniofacial
• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
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growth/size/body
• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
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hearing/vestibular/ear
• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
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limbs/digits/tail
• least severe relative to Tg(KRT5-Terf2)PMBlas or Tg(KRT5-Terf2)POBlas transgenic mice
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