About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dhx37em1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:6258465
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dhx37em1(IMPC)J/Dhx37em1(IMPC)J C57BL/6NJ-Dhx37em1(IMPC)J/Mmjax MGI:6492800
ht2
Dhx37em1(IMPC)J/Dhx37+ C57BL/6NJ-Dhx37em1(IMPC)J/Mmjax MGI:6771967


Genotype
MGI:6492800
hm1
Allelic
Composition
Dhx37em1(IMPC)J/Dhx37em1(IMPC)J
Genetic
Background
C57BL/6NJ-Dhx37em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhx37em1(IMPC)J mutation (2 available); any Dhx37 mutation (39 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype

Dhx37em1(IMPC)J/Dhx37em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as dying morulae. Mutants fail to hatch from the zona pellucida and never reach blastocyst stage in culture.

embryo
• in vitro, embryos fail to form blastocysts and are dead after 3 days in culture
• in vitro, embryos fail to hatch from the zona pellucida after 3 days in culture, never forming blastocysts
• embryos recovered at E3.5 appear as dying morulae

mortality/aging
• homozygous embryos are recovered at E3.5 (10% versus expected 25%, n=29) and appear as dying morulae; no homozygous embryos or excess resorption sites are observed at E7.5




Genotype
MGI:6771967
ht2
Allelic
Composition
Dhx37em1(IMPC)J/Dhx37+
Genetic
Background
C57BL/6NJ-Dhx37em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhx37em1(IMPC)J mutation (2 available); any Dhx37 mutation (39 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory