Phenotypes associated with this allele

• Allele Symbol: Dhx37^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6258465
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dhx37^em1(IMPC)J/Dhx37^em1(IMPC)J	C57BL/6NJ-Dhx37^em1(IMPC)J/Mmjax	MGI:6492800
ht2	Dhx37^em1(IMPC)J/Dhx37^+	C57BL/6NJ-Dhx37^em1(IMPC)J/Mmjax	MGI:6771967

Genotype
MGI:6492800

hm1

• Allelic Composition: Dhx37^em1(IMPC)J/Dhx37^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Dhx37^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Dhx37

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Dhx37^em1(IMPC)J/Dhx37^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as dying morulae. Mutants fail to hatch from the zona pellucida and never reach blastocyst stage in culture.

embryo

failure of blastocyst formation ( J:279207 )

• in vitro, embryos fail to form blastocysts and are dead after 3 days in culture

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro, embryos fail to hatch from the zona pellucida after 3 days in culture, never forming blastocysts

abnormal morula morphology ( J:279207 )

• embryos recovered at E3.5 appear as dying morulae

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at E3.5 (10% versus expected 25%, n=29) and appear as dying morulae; no homozygous embryos or excess resorption sites are observed at E7.5

Genotype
MGI:6771967

ht2

• Allelic Composition: Dhx37^em1(IMPC)J/Dhx37⁺
• Genetic Background: C57BL/6NJ-Dhx37^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Dhx37

behavior/neurological

increased grip strength ( J:211773 )

♂

IMPC - JAX

increased vertical activity ( J:211773 )

♀

IMPC - JAX