Phenotypes associated with this allele

• Allele Symbol: Ppp1r12b^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6259156
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp1r12b^em1(IMPC)J/Ppp1r12b^em1(IMPC)J	C57BL/6NJ-Ppp1r12b^em1(IMPC)J/Mmjax	MGI:6696868

Genotype
MGI:6696868

hm1

• Allelic Composition: Ppp1r12b^em1(IMPC)J/Ppp1r12b^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Ppp1r12b^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Ppp1r12b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased heart weight ( J:211773 , J:335272 )

• ratio of heart weight to tibia length is decreased (J:335272)

• however, ratios for lung and kidney weights to tibia length are similar to controls (J:335272)

IMPC - JAX ♂ (J:211773)

decreased heart left ventricle size ( J:335272 )

• decrease in left ventricular mass to body weight ratio compared to C57BL/6NJ controls

• left ventricular inner diameter at diastole and at systole are reduced compared to C57BL/6NJ controls

abnormal cardiovascular system physiology ( J:335272 )

• decrease in expression of some markers of cardiac remodeling compared to wild-type C57BL/6NJ controls

increased cardiac muscle contractility ( J:335272 )

• compared to C57BL/6NJ controls

growth/size/body

increased body weight ( J:335272 )

♀ • significant increase in females at 12 weeks of age with a trend to increased weight in males at the same age

integument

abnormal coat/ hair morphology ( J:211773 )

♂

IMPC - JAX

absent vibrissae ( J:211773 )

♂

IMPC - JAX

muscle

increased cardiac muscle contractility ( J:335272 )

• compared to C57BL/6NJ controls