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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Haus4em1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:6259158
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Haus4em1(IMPC)J/Haus4em1(IMPC)J C57BL/6NJ-Haus4em1(IMPC)J/Mmjax MGI:6492874
ht2
 		Haus4em1(IMPC)J/Haus4+ C57BL/6NJ-Haus4em1(IMPC)J/Mmjax MGI:7317000


Genotype
MGI:6492874
hm1
Allelic
Composition		 Haus4em1(IMPC)J/Haus4em1(IMPC)J
Genetic
Background		 C57BL/6NJ-Haus4em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Haus4em1(IMPC)J mutation (2 available); any Haus4 mutation (24 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Haus4em1(IMPC)J/Haus4em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 that appear as morulae, but no embryos at E7.5. Mutants hatch from the zona and form irregular outgrowths with trophectoderm and primitive endoderm cells but small/no inner cell mass colony.

embryo
embryonic growth retardation ( J:279207 )
• embryos recovered at E3.5 appear as morulae
absent inner cell mass ( J:279207 )
• in vitro outgrowth assays show apparent trophectoderm (TE) and primitive endoderm (PrE) cells but small/no ICM colony after 3 days in culture

growth/size/body
embryonic growth retardation ( J:279207 )
• embryos recovered at E3.5 appear as morulae

mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )
• homozygous embryos are present at E3.5 (33% versus expected 25%, n=27) and appear as morulae; no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system
abnormal embryo implantation ( J:279207 )
• in vitro, embryos hatch from the zona pellucida but form irregular outgrowths after 3 days in culture




Genotype
MGI:7317000
ht2
Allelic
Composition		 Haus4em1(IMPC)J/Haus4+
Genetic
Background		 C57BL/6NJ-Haus4em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Haus4em1(IMPC)J mutation (2 available); any Haus4 mutation (24 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory