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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Crb1em2Boc
endonuclease-mediated mutation 2, Bo Chang
MGI:6259426
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Crb1em2Boc/Crb1em2Boc D2.Cg-Crb1em2Boc/Boc MGI:7713406
cx2
 		Crb1em2Boc/Crb1em2Boc
Jak3m1J/Jak3m1J 		B6.Cg-Crb1em2Boc Jak3m1J/Boc MGI:7713417


Genotype
MGI:7713406
hm1
Allelic
Composition		 Crb1em2Boc/Crb1em2Boc
Genetic
Background		 D2.Cg-Crb1em2Boc/Boc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crb1em2Boc mutation (2 available); any Crb1 mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Early-onset multifocal depigmented retinal lesions in Crb1em2Boc/Crb1em2Boc Jak3m1J/Jak3m1J mice on a C57BL/6J background (A, B) but normal retinas in Crb1em2Boc/Crb1em2Boc mice on a DBA/2J background (C,D).

vision/eye
vision/eye phenotype ( J:353326 )
N
• On this DBA/2J congenic background, which is wild type at the Jak3 locus, there are no retinal abnormalities even at 6 months of age




Genotype
MGI:7713417
cx2
Allelic
Composition		 Crb1em2Boc/Crb1em2Boc
Jak3m1J/Jak3m1J
Genetic
Background		 B6.Cg-Crb1em2Boc Jak3m1J/Boc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crb1em2Boc mutation (2 available); any Crb1 mutation (92 available)
Jak3m1J mutation (8 available); any Jak3 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Early-onset multifocal depigmented retinal lesions in Crb1em2Boc/Crb1em2Boc Jak3m1J/Jak3m1J mice on a C57BL/6J background (A, B) but normal retinas in Crb1em2Boc/Crb1em2Boc mice on a DBA/2J background (C,D).

cardiovascular system
retina neovascularization ( J:353326 )
• early-onset multifocal depigmented retinal lesions, significant by 4 weeks of age

vision/eye
retina neovascularization ( J:353326 )
• early-onset multifocal depigmented retinal lesions, significant by 4 weeks of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory