Analysis Tools
behavior/neurological
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• in a resident-intruder assay, mice show an increase in sniffing/allogrooming behavior; further analysis with submissive strain of mice as intruders shows that mutant mice show increased allogrooming behavior on intruders
• however, mice show no defects in the open field assay, on the rotarod, anxiety in the elevated plus maze, self-grooming, marble burying, or in acoustic startle and prepulse inhibition
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• in a resident-intruder assay, mice show an increase in sniffing/allogrooming behavior indicating abnormal active social behavior; further analysis with submissive strain of mice as intruders shows that mutant mice show increased allogrooming behavior on intruders
• in the tube test of social dominance, both males and females win the matches against wild-type mice, indicating increased social dominance
• however, no difference in threatening and aggressive behavior are seen and mice show normal sociability, with mice showing preference for a stranger mouse to a novel object as in wild-type mice
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• pups emit fewer ultrasonic vocalization (USV) on P2, P4, and P6 and continue to emit USVs on P14, a time when wild-type pups stop
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nervous system
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• mice exhibit a reduction in dendritic spine density of medium spiny neurons in the dorsal striatum
• however, no reduction in hippocampal CA1 pyramidal neuron spine density is seen
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• medium spiny neurons in the dorsal striatum show reduced miniature excitatory postsynaptic currents (mEPSCs) frequency and amplitude
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:305052 | ||
