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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tut4tm2.1Doca
targeted mutation 2.1, Donal O'Carroll
MGI:6259529
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tut4tm2.1Doca/Tut4tm2.1Doca
Tut7tm2.1Doca/Tut7tm2.1Doca
Tg(Zp3-cre)93Knw/0 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J MGI:6259731
cn2
 		Tut4tm2.1Doca/Tut4tm3.1Doca
Tut7tm2.1Doca/Tut7tm2.1Doca
Tg(Zp3-cre)93Knw/0 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J MGI:6259733


Genotype
MGI:6259731
cn1
Allelic
Composition		 Tut4tm2.1Doca/Tut4tm2.1Doca
Tut7tm2.1Doca/Tut7tm2.1Doca
Tg(Zp3-cre)93Knw/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Zp3-cre)93Knw mutation (2 available)
Tut4tm2.1Doca mutation (0 available); any Tut4 mutation (81 available)
Tut7tm2.1Doca mutation (0 available); any Tut7 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal female meiosis I arrest ( J:262343 )
• most fail meiosis I with several phenotypic abnormalities, including abnormal spindle, telophase arrest and abnormal meiosis II oocytes
female infertility ( J:262343 )
• despite normal numbers of oocytes ovulated after hormonal stimulation
impaired fertilization ( J:262343 )
• in vitro, few oocytes are capable of fertilization and the small fraction that are fail to develop past the two-cell stage

cellular
abnormal female meiosis I arrest ( J:262343 )
• most fail meiosis I with several phenotypic abnormalities, including abnormal spindle, telophase arrest and abnormal meiosis II oocytes




Genotype
MGI:6259733
cn2
Allelic
Composition		 Tut4tm2.1Doca/Tut4tm3.1Doca
Tut7tm2.1Doca/Tut7tm2.1Doca
Tg(Zp3-cre)93Knw/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Zp3-cre)93Knw mutation (2 available)
Tut4tm2.1Doca mutation (0 available); any Tut4 mutation (81 available)
Tut4tm3.1Doca mutation (0 available); any Tut4 mutation (81 available)
Tut7tm2.1Doca mutation (0 available); any Tut7 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal female meiosis I arrest ( J:262343 )
• most fail meiosis I with several phenotypic abnormalities, including abnormal spindle
female infertility ( J:262343 )
• despite normal numbers of oocytes ovulated after hormonal stimulation
impaired fertilization ( J:262343 )
• in vitro, few oocytes are capable of fertilization and the small fraction that are fail to develop past the two-cell stage, telophase arrest and abnormal meiosis II oocytes

cellular
abnormal female meiosis I arrest ( J:262343 )
• most fail meiosis I with several phenotypic abnormalities, including abnormal spindle




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory