About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tut7tm2.1Doca
targeted mutation 2.1, Donal O'Carroll
MGI:6259530
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tut4tm2.1Doca/Tut4tm2.1Doca
Tut7tm2.1Doca/Tut7tm2.1Doca
Tg(Zp3-cre)93Knw/0 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J MGI:6259731
cn2
 		Tut4tm2.1Doca/Tut4tm3.1Doca
Tut7tm2.1Doca/Tut7tm2.1Doca
Tg(Zp3-cre)93Knw/0 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J MGI:6259733


Genotype
MGI:6259731
cn1
Allelic
Composition		 Tut4tm2.1Doca/Tut4tm2.1Doca
Tut7tm2.1Doca/Tut7tm2.1Doca
Tg(Zp3-cre)93Knw/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Zp3-cre)93Knw mutation (2 available)
Tut4tm2.1Doca mutation (0 available); any Tut4 mutation (81 available)
Tut7tm2.1Doca mutation (0 available); any Tut7 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal female meiosis I arrest ( J:262343 )
• most fail meiosis I with several phenotypic abnormalities, including abnormal spindle, telophase arrest and abnormal meiosis II oocytes
female infertility ( J:262343 )
• despite normal numbers of oocytes ovulated after hormonal stimulation
impaired fertilization ( J:262343 )
• in vitro, few oocytes are capable of fertilization and the small fraction that are fail to develop past the two-cell stage

cellular
abnormal female meiosis I arrest ( J:262343 )
• most fail meiosis I with several phenotypic abnormalities, including abnormal spindle, telophase arrest and abnormal meiosis II oocytes




Genotype
MGI:6259733
cn2
Allelic
Composition		 Tut4tm2.1Doca/Tut4tm3.1Doca
Tut7tm2.1Doca/Tut7tm2.1Doca
Tg(Zp3-cre)93Knw/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Zp3-cre)93Knw mutation (2 available)
Tut4tm2.1Doca mutation (0 available); any Tut4 mutation (81 available)
Tut4tm3.1Doca mutation (0 available); any Tut4 mutation (81 available)
Tut7tm2.1Doca mutation (0 available); any Tut7 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal female meiosis I arrest ( J:262343 )
• most fail meiosis I with several phenotypic abnormalities, including abnormal spindle
female infertility ( J:262343 )
• despite normal numbers of oocytes ovulated after hormonal stimulation
impaired fertilization ( J:262343 )
• in vitro, few oocytes are capable of fertilization and the small fraction that are fail to develop past the two-cell stage, telophase arrest and abnormal meiosis II oocytes

cellular
abnormal female meiosis I arrest ( J:262343 )
• most fail meiosis I with several phenotypic abnormalities, including abnormal spindle




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory