All Phenotypes Btbd7<tm1.1Kmy> MGI Mouse

postnatal lethality, complete penetrance ( J:241996 )

• mice that are born alive die within a few days of birth

lethality throughout fetal growth and development, incomplete penetrance ( J:241996 )

• decreased ratios of homozygous embryos between E13 and E17 with few born

prenatal growth retardation ( J:241996 )

• smaller than littermate controls at E13 and E17

endocrine/exocrine gland phenotype ( J:241996 )

N	• pancreatic branching morphogenesis appears similar to controls

abnormal submandibular gland development ( J:241996 )

• outer cells of the branching end buds are significantly more columnar and tightly packed compared to controls at E13.5 resembling outer cells of wild-type buds at E11.5

abnormal submandibular gland branching morphogenesis ( J:241996 )

• at E13.5 glands show a severe inhibition of branching with most having only a single bud

• glands cultured for 40h fail to branch much further unlike controls where bud numbers increase approximately nine-fold

• at E13.5 migration of outer bud cells is significantly slower compared to controls

• at E13.5 minimal basement membrane indentations form but fail to develop into true clefts unlike in controls

decreased submandibular gland size ( J:241996 )

• at E17.5, the few surviving embryos have very small glands

abnormal branching involved in lung morphogenesis ( J:241996 )

• decreased branching morphogenesis in cultured lungs from E13.5 embryos

impaired branching involved in ureteric bud morphogenesis ( J:241996 )

• decreased branching morphogenesis in cultured kidneys from E13.5 embryos

decreased cell migration ( J:241996 )

• at E13.5 migration of outer bud cells, but not inner bud cells, is significantly slower compared to controls