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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itm2cem1Nutt
endonuclease-mediated mutation 1, Stephen L Nutt
MGI:6260167
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Itm2cem1Nutt/Itm2cem1Nutt involves: C57BL/6J MGI:6281132
cx2
 		Itm2cem1Nutt/Itm2cem1Nutt
Prdm1tm1Nutt/Prdm1+ 		involves: C57BL/6 * C57BL/6J MGI:6281134


Genotype
MGI:6281132
hm1
Allelic
Composition		 Itm2cem1Nutt/Itm2cem1Nutt
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2cem1Nutt mutation (0 available); any Itm2c mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:265892 )
• mice are viable and fertile, show no overt physical defects or disease phenotype, and exhibit no differences in the development, maturation and differentiation of B-lymphocytes into antibody secreting cells or in immunoglobulin class-switch recombination relative to wild-type controls




Genotype
MGI:6281134
cx2
Allelic
Composition		 Itm2cem1Nutt/Itm2cem1Nutt
Prdm1tm1Nutt/Prdm1+
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2cem1Nutt mutation (0 available); any Itm2c mutation (19 available)
Prdm1tm1Nutt mutation (1 available); any Prdm1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:265892 )
N
• mice show no significant differences in the frequency of bone marrow plasma cells, splenic plasma cells and splenic plasmablasts, or in the serum concentrations of IgM, IgG1, IgG2b, IgG2c, IgG3 or IgA relative to wild-type controls




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory