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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chaf1btm2c(EUCOMM)Hmgu
targeted mutation 2c, Helmholtz Zentrum Muenchen GmbH
MGI:6260241
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Chaf1btm2c(EUCOMM)Hmgu/Chaf1b+
Krastm4Tyj/Kras+
Tg(Mx1-cre)1Cgn/0 		involves: 129S4/SvJae * C57BL/6J * C57BL/6N * CBA/J MGI:6267351
cn2
 		Chaf1btm2c(EUCOMM)Hmgu/Chaf1btm2c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca MGI:6267348
cn3
 		Chaf1btm2c(EUCOMM)Hmgu/Chaf1b+
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca MGI:6267349
cn4
 		Chaf1btm2c(EUCOMM)Hmgu/Chaf1btm2c(EUCOMM)Hmgu
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6J * C57BL/6N * CBA/J MGI:6267346
cn5
 		Chaf1btm2c(EUCOMM)Hmgu/Chaf1b+
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6J * C57BL/6N * CBA/J MGI:6267347


Genotype
MGI:6267351
cn1
Allelic
Composition		 Chaf1btm2c(EUCOMM)Hmgu/Chaf1b+
Krastm4Tyj/Kras+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * C57BL/6N * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chaf1btm2c(EUCOMM)Hmgu mutation (0 available); any Chaf1b mutation (36 available)
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:266848 )
• in pIpC-treated mice but not as severe as when Chaf1b alleles are wild-type

hematopoietic system
hematopoietic system phenotype ( J:266848 )
N
• pIpC-treated mice exhibit normal numbers of red blood cells and platelets
increased leukocyte cell number ( J:266848 )
• in pIpC-treated mice

immune system
increased leukocyte cell number ( J:266848 )
• in pIpC-treated mice




Genotype
MGI:6267348
cn2
Allelic
Composition		 Chaf1btm2c(EUCOMM)Hmgu/Chaf1btm2c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chaf1btm2c(EUCOMM)Hmgu mutation (0 available); any Chaf1b mutation (36 available)
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:266848 )
• no viable mice are produced




Genotype
MGI:6267349
cn3
Allelic
Composition		 Chaf1btm2c(EUCOMM)Hmgu/Chaf1b+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chaf1btm2c(EUCOMM)Hmgu mutation (0 available); any Chaf1b mutation (36 available)
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell morphology/development ( J:266848 )
• bone marrow cells from pIpC-treated mice fail to form fewer colonies in culture compared with control cell
decreased bone marrow cell number ( J:266848 )
• modest reduction in pIpC-treated mice
decreased hematopoietic stem cell number ( J:266848 )
• in the bone marrow cells from pIpC-treated mice with an increase in the percentage of LK cells, decrease in LSK cells and increased proportion of short-term SLAM+ cells




Genotype
MGI:6267346
cn4
Allelic
Composition		 Chaf1btm2c(EUCOMM)Hmgu/Chaf1btm2c(EUCOMM)Hmgu
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6J * C57BL/6N * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chaf1btm2c(EUCOMM)Hmgu mutation (0 available); any Chaf1b mutation (36 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:266848 )
• pIpC-treated mice die within two weeks of treatment

hematopoietic system
abnormal bone marrow cell morphology/development ( J:266848 )
• bone marrow cells from pIpC-treated mice fail to form colonies in culture
decreased bone marrow cell number ( J:266848 )
• in pIpC-treated mice
decreased hematopoietic cell number ( J:266848 )
• in the bone marrow of pIpC-treated mice
decreased hematopoietic stem cell number ( J:266848 )
• in the bone marrow cells from pIpC-treated mice
pancytopenia ( J:266848 )
• in pIpC-treated mice
abnormal bone marrow cell physiology ( J:266848 )
• increased apoptosis in the bone marrow of pIpC-treated mice
• bone marrow cells from pIpC-treated mice exhibit impaired hematopoietic reconstitution compared with with cells from control mice

cellular
increased apoptosis ( J:266848 )
• increased apoptosis in the bone marrow of pIpC-treated mice




Genotype
MGI:6267347
cn5
Allelic
Composition		 Chaf1btm2c(EUCOMM)Hmgu/Chaf1b+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6J * C57BL/6N * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chaf1btm2c(EUCOMM)Hmgu mutation (0 available); any Chaf1b mutation (36 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell morphology/development ( J:266848 )
• bone marrow cells from pIpC-treated mice fail to form fewer colonies in culture compared with control cell
decreased bone marrow cell number ( J:266848 )
• modest reduction in pIpC-treated mice
decreased hematopoietic stem cell number ( J:266848 )
• in the bone marrow cells from pIpC-treated mice with an increase in the percentage of LK cells, decrease in LSK cells and increased proportion of short-term SLAM+ cells
abnormal bone marrow cell physiology ( J:266848 )
• modest increase in apoptosis in the bone marrow of pIpC-treated mice

cellular
increased apoptosis ( J:266848 )
• modest increase in apoptosis in the bone marrow of pIpC-treated mice




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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory