Analysis Tools|
Allele Symbol Allele Name Allele ID |
Polr2bem1(IMPC)Bay endonuclease-mediated mutation 1, Baylor College of Medicine MGI:6266826 |
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| Summary |
3 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Polr2bem1(IMPC)Bay/Polr2bem1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as dying morulae. Mutants fail to hatch from the zona pellucida and and die after 3 days in culture.
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• homozygous embryos are recovered at E3.5 (11% versus 25%, n=8) and appear as dying morulae; no homozygous embryos or excess resorption sites are observed at E7.5
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• in vitro outgrowth assays show that embryos fail to hatch from the zona pellucida after 3 days in culture
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• embryos recovered at E3.5 appear as dying morulae
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• in vitro, embryos fail to hatch and are dead after 3 days in culture
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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