All Phenotypes Pls3<tm1d(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pls3^{tm1d(EUCOMM)Wtsi}
targeted mutation 1d, Wellcome Trust Sanger Institute
MGI:6266858

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pls3^{tm1d(EUCOMM)Wtsi}/Pls3^{tm1d(EUCOMM)Wtsi}	involves: BALB/cJ * C57BL/6N * C57BL/6NTac * SJL	MGI:6267048
ot2	Pls3^{tm1d(EUCOMM)Wtsi}/Y	involves: BALB/cJ * C57BL/6N * C57BL/6NTac * SJL	MGI:6267049

Allelic Composition	Pls3^{tm1d(EUCOMM)Wtsi}/Pls3^{tm1d(EUCOMM)Wtsi}
Genetic Background	involves: BALB/cJ * C57BL/6N * C57BL/6NTac * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pls3^{tm1d(EUCOMM)Wtsi} mutation (0 available); any Pls3 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:267292 )

N	• mice exhibit normal numbers of osteoclasts

decreased femur compact bone thickness ( J:267292 )

decreased bone volume ( J:267292 )

• in female, but not male, mice

decreased compact bone area ( J:267292 )

decreased bone trabecula number ( J:267292 )

• however, trabecular thickness is normal

increased bone trabecular spacing ( J:267292 )

osteoporosis ( J:267292 )

• in cortical and trabecular bone that is more prominent in males

abnormal skeleton physiology ( J:267292 )

• mild decrease of ultimate stress compared with wild-type mice

• however, bone strength and stiffness is normal

increased bone resorption ( J:267292 )

limbs/digits/tail

decreased femur compact bone thickness ( J:267292 )

Allelic Composition	Pls3^{tm1d(EUCOMM)Wtsi}/Y
Genetic Background	involves: BALB/cJ * C57BL/6N * C57BL/6NTac * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pls3^{tm1d(EUCOMM)Wtsi} mutation (0 available); any Pls3 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:267292 )

N	• mice exhibit normal numbers of osteoclasts

decreased femur compact bone thickness ( J:267292 )

decreased compact bone area ( J:267292 )

decreased bone trabecula number ( J:267292 )

increased bone trabecular spacing ( J:267292 )

osteoporosis ( J:267292 )

• in cortical and trabecular bone that is more prominent in males

abnormal skeleton physiology ( J:267292 )

• decreased ultimate stress compared with wild-type mice

increased bone resorption ( J:267292 )

decreased bone stiffness ( J:267292 )

decreased bone strength ( J:267292 )

limbs/digits/tail

decreased femur compact bone thickness ( J:267292 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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