Phenotypes associated with this allele

• Allele Symbol: Gpr108^tm1.1Brs
• Allele Name: targeted mutation 1.1, Brian Seed
• Allele ID: MGI:6267426
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr108^tm1.1Brs/Gpr108^tm1.1Brs	involves: 129S6/SvEvTac	MGI:6267454

Genotype
MGI:6267454

hm1

• Allelic Composition: Gpr108^tm1.1Brs/Gpr108^tm1.1Brs
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:266821 )

• all mice die within 10 hours of LPS treatment unlike wild-type mice

immune system

increased interleukin-6 secretion ( J:266821 )

• from bone marrow-derived macrophages

• from mouse embryonic fibroblasts stimulated with LPS

decreased tumor necrosis factor secretion ( J:266821 )

• from bone marrow-derived macrophages

increased tumor necrosis factor secretion ( J:266821 )

• from mouse embryonic fibroblasts stimulated with LPS

increased susceptibility to endotoxin shock ( J:266821 )

• all mice die within 10 hours of LPS treatment unlike wild-type mice

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:266821 )

• all mice die within 10 hours of LPS treatment unlike wild-type mice