Phenotypes associated with this allele

• Allele Symbol: Marchf3^em1Hbsh
• Allele Name: endonuclease-mediated mutation 1, Hong-Bing Shu
• Allele ID: MGI:6269174
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Marchf3^em1Hbsh/Marchf3^em1Hbsh	involves: C57BL/6J	MGI:6269175

Genotype
MGI:6269175

hm1

• Allelic Composition: Marchf3^em1Hbsh/Marchf3^em1Hbsh
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating cytokine level ( J:267641 )

• increased levels of serum proinflammatory cytokines (including Tnf and Il1b) after i.p. injection with interleukin 1 beta or L. monocytogenes

immune system

abnormal circulating cytokine level ( J:267641 )

• increased levels of serum proinflammatory cytokines (including Tnf and Il1b) after i.p. injection with interleukin 1 beta or L. monocytogenes

increased susceptibility to infection induced morbidity/mortality ( J:267641 )

• reduced levels of L. monocytogenes in spleen and liver compared to wild-type littermates at 2 d post-i.p. injection with L. monocytogenes

• increased inflammatory damage to lungs and small intestinal villi after i.p. injection with L. monocytogenes

• increased lethality after i.p. injection with L. monocytogenes

mortality/aging

increased susceptibility to infection induced morbidity/mortality ( J:267641 )

• reduced levels of L. monocytogenes in spleen and liver compared to wild-type littermates at 2 d post-i.p. injection with L. monocytogenes

• increased inflammatory damage to lungs and small intestinal villi after i.p. injection with L. monocytogenes

• increased lethality after i.p. injection with L. monocytogenes

abnormal susceptibility to induced morbidity/mortality ( J:267641 )

• increased lethality after i.p. injection with interleukin 1 beta plus D-galactosamine

• earlier onset of lethality after i.p. injection with interleukin 1 beta plus D-galactosamine