Phenotypes associated with this allele

• Allele Symbol: Lepr^m8Btlr
• Allele Name: mutation 8, Bruce Beutler
• Allele ID: MGI:6269382
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lepr^m8Btlr/Lepr^m8Btlr	C57BL/6J-Lepr^m8Btlr	MGI:6269384

Genotype
MGI:6269384

hm1

• Allelic Composition: Lepr^m8Btlr/Lepr^m8Btlr
• Genetic Background: C57BL/6J-Lepr^m8Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased effector memory CD4-positive, alpha-beta T cell number ( J:267679 )

• in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:267679 )

• in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:267679 )

• in the peripheral blood

growth/size/body

increased body fat mass ( J:267679 )

increased body weight ( J:267679 )

obese ( J:267679 )

behavior/neurological

impaired balance ( J:267679 )

• reduced balance and coordination on a rotating rod during a rotarod performance test

impaired coordination ( J:267679 )

• reduced balance and coordination on a rotating rod during a rotarod performance test

skeleton

short tibia ( J:267679 )

abnormal pelvic girdle bone morphology ( J:267679 )

• reduced pelvis length

adipose tissue

increased body fat mass ( J:267679 )

increased percent body fat/body weight ( J:267679 )

• reduced lean/fat ratios

cardiovascular system

decreased heart rate ( J:267679 )

decreased systemic arterial systolic blood pressure ( J:267679 )

limbs/digits/tail

short tibia ( J:267679 )

liver/biliary system

hepatic steatosis ( J:267679 )

hematopoietic system

increased effector memory CD4-positive, alpha-beta T cell number ( J:267679 )

• in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:267679 )

• in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:267679 )

• in the peripheral blood