Phenotypes associated with this allele

• Allele Symbol: Lig4^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:6269393
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lig4^m1Btlr/Lig4^m1Btlr	C57BL/6J-Lig4^m1Btlr	MGI:6269395

Genotype
MGI:6269395

hm1

• Allelic Composition: Lig4^m1Btlr/Lig4^m1Btlr
• Genetic Background: C57BL/6J-Lig4^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell number ( J:267684 )

• in the peripheral blood

increased NK cell number ( J:267684 )

• in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:267684 )

decreased CD4-positive, alpha-beta T cell number ( J:267684 )

decreased CD8-positive, naive alpha-beta T cell number ( J:267684 )

increased CD8-positive, alpha-beta T cell number ( J:267684 )

increased central memory CD8 positive, alpha-beta T cell number ( J:267684 )

decreased IgD level ( J:267684 )

• on B cells in the peripheral blood

decreased IgG level ( J:267684 )

• dimished T-dependent antibody response to ovalbumin administered with aluminum hydroxide

impaired humoral immune response ( J:267684 )

• dimished T-dependent antibody response to ovalbumin administered with aluminum hydroxide

hematopoietic system

decreased B cell number ( J:267684 )

• in the peripheral blood

increased NK cell number ( J:267684 )

• in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:267684 )

decreased CD4-positive, alpha-beta T cell number ( J:267684 )

decreased CD8-positive, naive alpha-beta T cell number ( J:267684 )

increased CD8-positive, alpha-beta T cell number ( J:267684 )

increased central memory CD8 positive, alpha-beta T cell number ( J:267684 )

decreased IgD level ( J:267684 )

• on B cells in the peripheral blood

decreased IgG level ( J:267684 )

• dimished T-dependent antibody response to ovalbumin administered with aluminum hydroxide