Phenotypes associated with this allele

• Allele Symbol: Trim13^tm1.1Jskg
• Allele Name: targeted mutation 1.1, Joonsoo Kang
• Allele ID: MGI:6270360
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim13^tm1.1Jskg/Trim13^tm1.1Jskg	B6.129S7(Cg)-Trim13^tm1.1Jskg	MGI:6270368

Genotype
MGI:6270368

hm1

• Allelic Composition: Trim13^tm1.1Jskg/Trim13^tm1.1Jskg
• Genetic Background: B6.129S7(Cg)-Trim13^tm1.1Jskg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:243916 )

♀ • female mice infected with a lethal dose of encephalomyocarditis virus (EMCV) have a mean survival time of 143.3 h after infection compared with wild-type mice that survive 101.4 h

♀ • however, male mice exhibit normal survival and mice infected with vesicular stomatitis virus (VSV) exhibit normal survival

immune system

abnormal circulating interferon level ( J:243916 )

♀ • increased type I IFN serum levels 5 h after infection with a high dose of EMCV in female mice

♀ • however, response to influenza A virus infection is normal

decreased circulating interferon-beta level ( J:243916 )

♀ • 20 h after intranasal VSV infection in female mice

increased interferon-beta secretion ( J:243916 )

• from mouse embryonic fibroblasts exposed to poly(I.C) or EMCV

• however, response to Sendai virus is normal

decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:243916 )

♀ • female mice infected with a lethal dose of encephalomyocarditis virus (EMCV) have a mean survival time of 143.3 h after infection compared with wild-type mice that survive 101.4 h

♀ • however, male mice exhibit normal survival and mice infected with vesicular stomatitis virus (VSV) exhibit normal survival

homeostasis/metabolism

abnormal circulating interferon level ( J:243916 )

♀ • increased type I IFN serum levels 5 h after infection with a high dose of EMCV in female mice

♀ • however, response to influenza A virus infection is normal

decreased circulating interferon-beta level ( J:243916 )

♀ • 20 h after intranasal VSV infection in female mice