Phenotypes associated with this allele

• Allele Symbol: Rsf1^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6270386
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rsf1^tm1c(EUCOMM)Wtsi/Rsf1^tm1c(EUCOMM)Wtsi Tg(Nes-cre)1Kln/0	involves: C57BL/6N * SJL	MGI:6367647

Genotype
MGI:6367647

cn1

• Allelic Composition: Rsf1^{tm1c(EUCOMM)Wtsi}/Rsf1^{tm1c(EUCOMM)Wtsi}; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6N * SJL
• Cell Lines: EPD0103_1_F12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:267928 )

N • mice exhibit normal brain development

decreased neuron apoptosis ( J:267928 )

• in etoposide-treated embryonic brains

• however, response to hydroxyurea treatment is normal

cellular

decreased neuron apoptosis ( J:267928 )

• in etoposide-treated embryonic brains

• however, response to hydroxyurea treatment is normal

abnormal double-strand DNA break repair ( J:267928 )

• etoposide-treated embryonic exhibit persistence of double-strand breaks in surviving cells unlike wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:267928 )

N • mice do not show signs of ataxia

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:267928 )

• etoposide-treated embryonic exhibit persistence of double-strand breaks in surviving cells unlike wild-type mice