Phenotypes associated with this allele

• Allele Symbol: Tph1^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6271993
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tph1^tm1c(KOMP)Wtsi/Tph1^tm1c(KOMP)Wtsi Tg(Ins2-cre)23Herr/0	involves: 129S4/SvJae * C57BL/6J * CBA/J	MGI:6400799

Genotype
MGI:6400799

cn1

• Allelic Composition: Tph1^{tm1c(KOMP)Wtsi}/Tph1^{tm1c(KOMP)Wtsi}; Tg(Ins2-cre)23Herr/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased pancreatic beta cell proliferation ( J:284574 )

• decreased perinatal beta cell proliferation without an increase in apoptosis

• however, adult beta cell proliferation is normal and mice exhibit S-961-induced proliferation

decreased pancreatic beta cell mass ( J:284574 )

• without a change in pancreas size

homeostasis/metabolism

impaired glucose tolerance ( J:284574 )

• at 9 weeks of age when fed standard chow or when fed a high-fat diet

decreased physiological sensitivity to xenobiotic ( J:284574 )

• following tolbutamide treatment, P0 pancreas fails to exhibit an increase in serotonin secretion unlike control pancreas

cellular

decreased pancreatic beta cell proliferation ( J:284574 )

• decreased perinatal beta cell proliferation without an increase in apoptosis

• however, adult beta cell proliferation is normal and mice exhibit S-961-induced proliferation