Phenotypes associated with this allele

• Allele Symbol: Il36a^tm1Yiw
• Allele Name: targeted mutation 1, Yoichiro Iwakura
• Allele ID: MGI:6272256
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il36a^tm1Yiw/Il36a^tm1Yiw	B6.129P2-Il36a^tm1Yiw	MGI:6473263

Genotype
MGI:6473263

hm1

• Allelic Composition: Il36a^tm1Yiw/Il36a^tm1Yiw
• Genetic Background: B6.129P2-Il36a^tm1Yiw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal cytokine level ( J:263315 )

• qPCR analysis revealed a significant downregulation of expression of Th17-related proinflammatory cytokine and chemokine genes (Il6, Il1a, Il1b, Il17c, Il17f, Cxcl2, and S100a9) and a trend towards reduced Il17a gene expression in IMQ-treated mouse ear skin

decreased physiological sensitivity to xenobiotic ( J:263315 )

• mice treated with imiquimod cream (IMQ, a ligand for TLR7/8) develop less severe dermatitis with significantly reduced ear lobe swelling relative to IMQ-treated wild-type controls under both cohoused and separately housed conditions

• antibiotic-treated mice show significantly less ear swelling than antibiotic-treated wild-type controls, suggesting that suppression of IMQ-induced dermatitis is not mediated by a change in commensal microbiota

• IMQ-treated mice show attenuated psoriasiform skin pathology with significantly lower redness, scaling and cumulative scores, reduced epidermal thickness, and milder hyperkeratosis, parakeratosis, spongiosis, acanthosis and microabscess formation in the ear lobes than IMQ-treated wild-type controls under both cohoused and separately housed conditions

• no significant difference in IMQ-induced dermatitis severity is noted between separate and cohoused groups

immune system

immune system phenotype ( J:263315 )

N • mice show normal development of dextran sodium sulfate (DSS)-induced colitis in terms of disease onset and severity relative to DSS-treated wild-type controls under both cohoused and separately housed conditions

abnormal cytokine level ( J:263315 )

• qPCR analysis revealed a significant downregulation of expression of Th17-related proinflammatory cytokine and chemokine genes (Il6, Il1a, Il1b, Il17c, Il17f, Cxcl2, and S100a9) and a trend towards reduced Il17a gene expression in IMQ-treated mouse ear skin

digestive/alimentary system

digestive/alimentary phenotype ( J:263315 )

N • mice show normal development of dextran sodium sulfate (DSS)-induced colitis in terms of disease onset and severity relative to DSS-treated wild-type controls under both cohoused and separately housed conditions