All Phenotypes Tg(Tyr-Ctnnb1/EGFP)#Lru MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-Ctnnb1/EGFP)#Lru/0
Genetic Background	B6.Cg-Tg(Tyr-Ctnnb1/EGFP)#Lru Tg(Dct-lacZ)A12Jkn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Dct-lacZ)A12Jkn mutation (5 available)
Tg(Tyr-Ctnnb1/EGFP)#Lru mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased melanoblast proliferation ( J:176245 )

• overall, melanoblasts exhibit a lower level of BrdU incorporation in the epidermis (E12.5 to E14.5) and dermis (E13.5) relative to wild-type controls

• however, no differences in apoptosis, cell differentiation or fate are observed

abnormal melanoblast morphology ( J:176245 )

• in the trunk region, melanoblast number is normal at E10.5 but significantly lower than that in wild-type controls at each developmental stage from E11.5 to E15.5; this difference increases with time

• although melanoblast numbers are reduced in both the epidermis and dermis, the reduction is far greater in the epidermis than in the dermis

cellular

decreased melanoblast proliferation ( J:176245 )

• overall, melanoblasts exhibit a lower level of BrdU incorporation in the epidermis (E12.5 to E14.5) and dermis (E13.5) relative to wild-type controls

• however, no differences in apoptosis, cell differentiation or fate are observed

nervous system

abnormal melanoblast morphology ( J:176245 )

• although melanoblast numbers are reduced in both the epidermis and dermis, the reduction is far greater in the epidermis than in the dermis

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal hair follicle melanogenesis ( J:176245 )

• at 7 days of age, mice show gray pigmentation in the hair follicle bulbs rather the dark pigmentation seen in wild-type controls

reduced hair shaft melanin granule number ( J:176245 )

• spectrophotometry revealed that hair melanin content is lower than that in wild-type controls

• however, melanin is distributed uniformly from the root to the apex as in wild-type hairs

abnormal pinna hair pigmentation ( J:176245 )

• mice exhibit gray ears, similar to their coat pigmentation

abnormal tail hair pigmentation ( J:176245 )

• mice exhibit gray tails, similar to their coat pigmentation

diluted coat color ( J:176245 )

• mice exhibit a gray coat, unlike the black coat color of wild-type controls

• transgenic hairs show a lighter pigmentation than wild-type hairs

integument