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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smcr8m1Btlr
mutation 1, Bruce Beutler
MGI:6272372
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smcr8m1Btlr/Smcr8m1Btlr C57BL/6J-Smcr8m1Btlr MGI:6272633
ht2
 		Smcr8m1Btlr/Smcr8+ C57BL/6J-Smcr8m1Btlr MGI:6272634


Genotype
MGI:6272633
hm1
Allelic
Composition		 Smcr8m1Btlr/Smcr8m1Btlr
Genetic
Background		 C57BL/6J-Smcr8m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smcr8m1Btlr mutation (0 available); any Smcr8 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to induced colitis ( J:268243 )
• dextran sulfate sodium (DSS)-induced
increased tumor necrosis factor secretion ( J:268243 )
• in response to the TLR9 ligand CpG

digestive/alimentary system
increased susceptibility to induced colitis ( J:268243 )
• dextran sulfate sodium (DSS)-induced




Genotype
MGI:6272634
ht2
Allelic
Composition		 Smcr8m1Btlr/Smcr8+
Genetic
Background		 C57BL/6J-Smcr8m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smcr8m1Btlr mutation (0 available); any Smcr8 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to induced colitis ( J:268243 )
• dextran sulfate sodium (DSS)-induced

digestive/alimentary system
increased susceptibility to induced colitis ( J:268243 )
• dextran sulfate sodium (DSS)-induced




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory