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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wdr41m2Btlr
mutation 2, Bruce Beutler
MGI:6272390
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wdr41m2Btlr/Wdr41m2Btlr C57BL/6J-Wdr41m2Btlr MGI:6272621


Genotype
MGI:6272621
hm1
Allelic
Composition		 Wdr41m2Btlr/Wdr41m2Btlr
Genetic
Background		 C57BL/6J-Wdr41m2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wdr41m2Btlr mutation (0 available); any Wdr41 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased CD4-positive, alpha-beta T cell number ( J:268243 )
• increased frequency of activated Cd4+ (CD44+CD62L CD4+) T cells in the peripheral blood
increased CD8-positive, alpha-beta T cell number ( J:268243 )
• increased frequency of activated Cd4+ (CD44+CD62L CD8+) T cells in the peripheral blood
increased tumor necrosis factor secretion ( J:268243 )
• in response to the TLR9 ligand CpG, TLR3 ligand poly(I:C), and the TLR7 ligand R848

hematopoietic system
increased CD4-positive, alpha-beta T cell number ( J:268243 )
• increased frequency of activated Cd4+ (CD44+CD62L CD4+) T cells in the peripheral blood
increased CD8-positive, alpha-beta T cell number ( J:268243 )
• increased frequency of activated Cd4+ (CD44+CD62L CD8+) T cells in the peripheral blood




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory