Phenotypes associated with this allele

• Allele Symbol: Thra^em1Ffla
• Allele Name: endonuclease-mediated mutation 1, Frederic Flamant
• Allele ID: MGI:6272829
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Thra^em1Ffla/Thra^+	C57BL/6-Thra^em1Ffla	MGI:6317178

Genotype
MGI:6317178

ht1

• Allelic Composition: Thra^em1Ffla/Thra⁺
• Genetic Background: C57BL/6-Thra^em1Ffla

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:268664 )

N • tibia lengths and bone thickness are normal

short femur ( J:268664 )

• in female and male mice

decreased trabecular bone thickness ( J:268664 )

• with increased trabecular bone surface

delayed endochondral bone ossification ( J:268664 )

• incomplete ossification in long bones at P15 with persistence of thick cartilage plates at the extremities, particularly in the tail

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:268664 )

N • mice exhibit normal IL1beta serum levels

increased triiodothyronine level ( J:268664 )

• modest increase of free T3

hematopoietic system

decreased hemoglobin content ( J:268664 )

• slight without a change in spleen size

cellular

abnormal enterocyte proliferation ( J:268664 )

• decreased proliferation of cells in the colon and ileum

digestive/alimentary system

abnormal enterocyte proliferation ( J:268664 )

• decreased proliferation of cells in the colon and ileum

limbs/digits/tail

short femur ( J:268664 )

• in female and male mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid hormone resistance syndrome		DOID:11633	OMIM:188570 OMIM:274300	J:268664