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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrrk2tm4.1Arte
targeted mutation 4.1, TaconicArtemis
MGI:6273209
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Lrrk2tm4.1Arte/Lrrk2+ C57BL/6-Lrrk2tm4.1Arte/Tac MGI:6798089


Genotype
MGI:6798089
ht1
Allelic
Composition		 Lrrk2tm4.1Arte/Lrrk2+
Genetic
Background		 C57BL/6-Lrrk2tm4.1Arte/Tac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrk2tm4.1Arte mutation (0 available); any Lrrk2 mutation (160 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain interneuron morphology ( J:312767 )
• loss of primary cilia on choline acetyltransferase interneurons of the dorsal striatum that is less severe than in Tg(LRRK2*G2019S)2AMjff mice
• fewer and shorter cilia on striatal astrocytes
• treatment with an LRRK2 inhibitor (MLi- 2) fails to restore cilia
• however, cilia on primarily medium spiny neurons are normal
abnormal dorsal striatum morphology ( J:312767 )
• loss of primary cilia on choline acetyltransferase interneurons of the dorsal striatum that is less severe than in Tg(LRRK2*G2019S)2AMjff mice
• fewer and shorter cilia on striatal astrocytes
• treatment with an LRRK2 inhibitor (MLi- 2) fails to restore cilia
• however, cilia on primarily medium spiny neurons are normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory