About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrrk2tm4.1Arte
targeted mutation 4.1, TaconicArtemis
MGI:6273209
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Lrrk2tm4.1Arte/Lrrk2+ C57BL/6-Lrrk2tm4.1Arte/Tac MGI:6798089


Genotype
MGI:6798089
ht1
Allelic
Composition		 Lrrk2tm4.1Arte/Lrrk2+
Genetic
Background		 C57BL/6-Lrrk2tm4.1Arte/Tac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrk2tm4.1Arte mutation (0 available); any Lrrk2 mutation (160 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain interneuron morphology ( J:312767 )
• loss of primary cilia on choline acetyltransferase interneurons of the dorsal striatum that is less severe than in Tg(LRRK2*G2019S)2AMjff mice
• fewer and shorter cilia on striatal astrocytes
• treatment with an LRRK2 inhibitor (MLi- 2) fails to restore cilia
• however, cilia on primarily medium spiny neurons are normal
abnormal dorsal striatum morphology ( J:312767 )
• loss of primary cilia on choline acetyltransferase interneurons of the dorsal striatum that is less severe than in Tg(LRRK2*G2019S)2AMjff mice
• fewer and shorter cilia on striatal astrocytes
• treatment with an LRRK2 inhibitor (MLi- 2) fails to restore cilia
• however, cilia on primarily medium spiny neurons are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory