normal phenotype
• mice are viable and overtly normal and show no detectable defects in intestinal epithelium cell differentiation
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Allele Symbol Allele Name Allele ID |
Tmem9tm1d(EUCOMM)Wtsi targeted mutation 1d, Wellcome Trust Sanger Institute MGI:6273211 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice are viable and overtly normal and show no detectable defects in intestinal epithelium cell differentiation
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit a median survival of 323 days versus 124 days in ApcMin heterozygotes
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• at 3 months of age, the number of intestinal adenomas is significantly lower than that in ApcMin heterozygotes
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• at 3 months of age, intestinal adenomas show downregulation of Wnt/beta-catenin target genes, reduced cell proliferation, and a decreased number of nuclear beta-catenin-positive cells relative to those in ApcMin heterozygotes
• however, no differences in apoptosis or epithelial-mesenchymal transition are observed
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• at 3 months of age, the size of intestinal adenomas is slightly smaller than that in ApcMin heterozygotes
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• at 3 months of age, the number of intestinal adenomas is significantly lower than that in ApcMin heterozygotes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit a median survival of 199 days versus 124 days in ApcMin heterozygotes
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• at 3 months of age, the number of intestinal adenomas is significantly lower than that in ApcMin heterozygotes
• however, tumor size is not significantly changed despite a reduction in cell proliferation
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• at 3 months of age, the number of intestinal adenomas is significantly lower than that in ApcMin heterozygotes
• however, tumor size is not significantly changed despite a reduction in cell proliferation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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