All Phenotypes Comt<tm1.1Tunb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Comt^tm1.1Tunb
targeted mutation 1.1, Elizabeth Tunbridge
MGI:6274226

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Comt^tm1.1Tunb/Comt^tm1.1Tunb	B6J.129-Comt^tm1.1Tunb	MGI:6274510

Allelic Composition	Comt^tm1.1Tunb/Comt^tm1.1Tunb
Genetic Background	B6J.129-Comt^tm1.1Tunb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Comt^tm1.1Tunb mutation (1 available); any Comt mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:269121 )

N	• normal performance in anxiety-related tasks, short term memory, novel object recognition, and long-term spatial memory performance

abnormal cognition ( J:269121 )

abnormal spatial working memory ( J:269121 )

• increased spatial novelty preference

cognitive inflexibility ( J:269121 )

• following administration of the COMT inhibitor, tocapone, performance on 5 choice serial reaction time test was not improved as compared to controls

abnormal impulsive behavior control ( J:269121 )

• following administration of the COMT inhibitor, tocapone, performance on 5 choice serial reaction time test was not improved as compared to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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