Phenotypes associated with this allele

• Allele Symbol: Comt^tm1.1Tunb
• Allele Name: targeted mutation 1.1, Elizabeth Tunbridge
• Allele ID: MGI:6274226
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Comt^tm1.1Tunb/Comt^tm1.1Tunb	B6J.129-Comt^tm1.1Tunb	MGI:6274510

Genotype
MGI:6274510

hm1

• Allelic Composition: Comt^tm1.1Tunb/Comt^tm1.1Tunb
• Genetic Background: B6J.129-Comt^tm1.1Tunb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:269121 )

N • normal performance in anxiety-related tasks, short term memory, novel object recognition, and long-term spatial memory performance

abnormal cognition ( J:269121 )

abnormal spatial working memory ( J:269121 )

• increased spatial novelty preference

cognitive inflexibility ( J:269121 )

• following administration of the COMT inhibitor, tocapone, performance on 5 choice serial reaction time test was not improved as compared to controls

abnormal impulsive behavior control ( J:269121 )

• following administration of the COMT inhibitor, tocapone, performance on 5 choice serial reaction time test was not improved as compared to controls