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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlk2tm1.2Strc
targeted mutation 1.2, Travis H Stracker
MGI:6274362
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tlk2tm1.2Strc/Tlk2tm1.2Strc involves: 129S/SvEv * C3H * C57BL/6 MGI:6274367
cn2
 		Tlk2tm1.1Strc/Tlk2tm1.2Strc
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129S/SvEv * C3H * C57BL/6 MGI:6274368


Genotype
MGI:6274367
hm1
Allelic
Composition		 Tlk2tm1.2Strc/Tlk2tm1.2Strc
Genetic
Background		 involves: 129S/SvEv * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlk2tm1.2Strc mutation (0 available); any Tlk2 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal placenta vasculature ( J:268910 )
• poorly vascularized from E10.5 - E16.5
abnormal placenta labyrinth morphology ( J:268910 )
• disorganized and composed of less differentiated and less mature trophoblasts at E10.5 - E12.5
small placenta ( J:268910 )
• moderately to severely smaller, thinner and less cellular from E10.5 - E16.5
abnormal trophoblast layer morphology ( J:268910 )
• moderately to severely reduced numbers of labyrinth trophoblast, syncytiotrophoblast, and spongiotrophoblast cells
decreased trophoblast giant cell number ( J:268910 )
• mildly to moderately reduced numbers of trophoblastic giant cells
decreased spongiotrophoblast cell number ( J:268910 )
• moderately to severely reduced numbers
abnormal syncytiotrophoblast morphology ( J:268910 )
• moderately to severely reduced numbers

cardiovascular system
abnormal placenta vasculature ( J:268910 )
• poorly vascularized from E10.5 - E16.5




Genotype
MGI:6274368
cn2
Allelic
Composition		 Tlk2tm1.1Strc/Tlk2tm1.2Strc
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S/SvEv * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Tlk2tm1.1Strc mutation (0 available); any Tlk2 mutation (71 available)
Tlk2tm1.2Strc mutation (0 available); any Tlk2 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:268910 )
• viable with similar growth capacity and no increase in morbidity at up to 18 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory