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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmem102tm1.1Jyen
targeted mutation 1.1, Jeffrey Yen
MGI:6274402
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmem102tm1.1Jyen/Tmem102tm1.1Jyen B6.Cg-Tmem102tm1.1Jyen MGI:6286348


Genotype
MGI:6286348
hm1
Allelic
Composition		 Tmem102tm1.1Jyen/Tmem102tm1.1Jyen
Genetic
Background		 B6.Cg-Tmem102tm1.1Jyen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem102tm1.1Jyen mutation (0 available); any Tmem102 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cell chemotaxis ( J:200103 )
• decreased migration and adhesion of nave T cells in response to chemokines CXCL12 and CCL21 and of activated T cells in response to CXCL12, CCL5, CXCL10 and CCL20 in vitro
• migration of donor T cells into spleen of wildtype hosts
• 24% decreased migration of donor T cells into lymph nodes of wildtype hosts
abnormal leukocyte adhesion ( J:200103 )
• decreased migration and adhesion of nave T cells in response to chemokines CXCL12 and CCL21 and of activated T cells in response to CXCL12, CCL5, CXCL10 and CCL20 in vitro
impaired leukocyte migration ( J:200103 )
• decreased migration and adhesion of nave T cells in response to chemokines CXCL12 and CCL21 and of activated T cells in response to CXCL12, CCL5, CXCL10 and CCL20 in vitro
• 24% decreased migration of donor T cells into lymph nodes of wildtype hosts
• migration of donor T cells into spleen of wildtype hosts

hematopoietic system
abnormal leukocyte adhesion ( J:200103 )
• decreased migration and adhesion of nave T cells in response to chemokines CXCL12 and CCL21 and of activated T cells in response to CXCL12, CCL5, CXCL10 and CCL20 in vitro
impaired leukocyte migration ( J:200103 )
• decreased migration and adhesion of nave T cells in response to chemokines CXCL12 and CCL21 and of activated T cells in response to CXCL12, CCL5, CXCL10 and CCL20 in vitro
• 24% decreased migration of donor T cells into lymph nodes of wildtype hosts
• migration of donor T cells into spleen of wildtype hosts

immune system
abnormal leukocyte adhesion ( J:200103 )
• decreased migration and adhesion of nave T cells in response to chemokines CXCL12 and CCL21 and of activated T cells in response to CXCL12, CCL5, CXCL10 and CCL20 in vitro
impaired leukocyte migration ( J:200103 )
• decreased migration and adhesion of nave T cells in response to chemokines CXCL12 and CCL21 and of activated T cells in response to CXCL12, CCL5, CXCL10 and CCL20 in vitro
• 24% decreased migration of donor T cells into lymph nodes of wildtype hosts
• migration of donor T cells into spleen of wildtype hosts




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory