All Phenotypes Mir22<tm1Boet> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mir22^tm1Boet
targeted mutation 1, Thomas Boettger
MGI:6274717

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir22^tm1Boet/Mir22^tm1Boet	B6.129S2-Mir22^tm1Boet	MGI:6274738
cn2	Esr1^tm4.2Ksk/Esr1^tm4.2Ksk Mir22^tm1Boet/Mir22^tm1Boet Tg(Ckmm-cre)5Khn/0	involves: 129S2/SvPas * C57BL/6 * FVB	MGI:6275157
cx3	Esr1^tm4.2Ksk/Esr1^tm4.2Ksk Mir22^tm1Boet/Mir22^tm1Boet	involves: 129S2/SvPas * C57BL/6	MGI:6275156

Allelic Composition	Mir22^tm1Boet/Mir22^tm1Boet
Genetic Background	B6.129S2-Mir22^tm1Boet

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir22^tm1Boet mutation (0 available); any Mir22 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:266382 )

N	• mice exhibit normal respiratory exchange quotient, blood glucose concentration and plasma triglyceride levels

increased fatty acid oxidation ( J:266382 )

• total, extramitochondrial and mitochondrial in muscle cells

decreased circulating leptin level ( J:266382 )

• in male mice

decreased circulating free fatty acids level ( J:266382 )

• in fasted male mice

• however, fed levels are normal

adipose tissue

decreased white adipose tissue amount ( J:266382 )

• in male mice

decreased white fat cell size ( J:266382 )

• in male mice

growth/size/body

decreased body weight ( J:266382 )

• in male, but not female, mice after 6 weeks

behavior/neurological

behavior/neurological phenotype ( J:266382 )

N	• mice exhibit normal food intake and locomotor activity

muscle

muscle phenotype ( J:266382 )

N	• mice exhibit normal muscle fiber composition and mitochondrial content

cellular

increased fatty acid oxidation ( J:266382 )

• total, extramitochondrial and mitochondrial in muscle cells

Allelic Composition	Esr1^tm4.2Ksk/Esr1^tm4.2Ksk Mir22^tm1Boet/Mir22^tm1Boet Tg(Ckmm-cre)5Khn/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1^tm4.2Ksk mutation (1 available); any Esr1 mutation (68 available)
Mir22^tm1Boet mutation (0 available); any Mir22 mutation (6 available)
Tg(Ckmm-cre)5Khn mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased fatty acid oxidation ( J:266382 )

• mitochondrial in muscle cells

• however, muscle cells exhibit normal total and extramitochondrial fatty acid oxidation

adipose tissue

adipose tissue phenotype ( J:266382 )

N	• mice exhibit normal fat amounts unlike mice homozygous for a knock-out allele of Mir22^tm1Boet

growth/size/body

growth/size/body region phenotype ( J:266382 )

N	• male and female mice exhibit normal body weight

muscle

muscle phenotype ( J:266382 )

N	• mice exhibit normal muscle fiber composition and mitochondrial content

cellular

increased fatty acid oxidation ( J:266382 )

• mitochondrial in muscle cells

• however, muscle cells exhibit normal total and extramitochondrial fatty acid oxidation

Allelic Composition	Esr1^tm4.2Ksk/Esr1^tm4.2Ksk Mir22^tm1Boet/Mir22^tm1Boet
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:266382 )

N	• male and female mice exhibit normal body weight

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