Analysis Tools
mortality/aging
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• mice exhibit increased mortality after 16 weeks of age
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behavior/neurological
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• mice perform less well on the treadmill test, spending less time on the treadmill and having a lower workload performed, indicating compromised exercise capacity
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cardiovascular system
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• mice have a modest, but significant, increase in heart rate at baseline
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• ventricular effective refractory period is prolonged
• however, mice do not exhibit conduction abnormalities, with normal sinus rhythm activation patterns and conduction velocities in pacing experiments
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• decrease in R-R interval
• however, other hemodynamic parameters, including left ventricular end-diastolic pressure, +dP/dt, -dP/dt, and the relaxation constant Tau are unchanged, indicating unchanged ventricular function
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• action potential duration in cardiac myocytes under current-clamp conditions are prolonged and isoproterenol leads to action potential prolongation with some myocytes developing early afterdepolarizations
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• ventricular myocytes exhibit smaller current density at 0 mV and dinitrophenol, pinacidil or bimakalim fail to activate sarcolemmal ATP-sensitive K+ channels in cardiac myocytes indicating that mice lack sarcolemmal ATP-sensitive K+ channels
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homeostasis/metabolism
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• mice perform less well on the treadmill test, spending less time on the treadmill and having a lower workload performed, indicating compromised exercise capacity
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