cardiovascular system
• mice exhibit impaired coronary function, showing elevated basal coronary perfusion pressure of isolated hearts at a constant flow rate
• mice show elevated release of the vasoconstrictor endothelin-1 in the coronary effluent from hearts
• treatment with the ATP-sensitive K+ channel blocker glibenclamide fails to produce a vasoconstrictive response as in controls
• mice pretreated with the endothelin-1 receptor antagonist bosentan show normal coronary perfusion pressure
• mice exhibit normal response to coronary vasospasm induced with ergonovine
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growth/size/body
N |
• mice exhibit normal body weight and wet heart weight
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mortality/aging
N |
• mice exhibit a normal lifespan
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