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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(ACTB-EGFP,-Kcnj8*)1Wco
transgene insertion 1, William A Coetzee
MGI:6275065
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(ACTB-EGFP,-Kcnj8*)1Wco/0
Tg(Tek-cre)12Flv/0 		involves: C3H * C57BL/6 * FVB/N MGI:6275068
cn2
 		Tg(ACTB-EGFP,-Kcnj8*)1Wco/0
Tg(Myh6-cre)2182Mds/0 		involves: FVB/N MGI:6275067
cn3
 		Tg(ACTB-EGFP,-Kcnj8*)1Wco/0
Tg(Myh11-icre/ERT2)1Soff/0 		involves: FVB/N MGI:6275077
tg4
 		Tg(ACTB-EGFP,-Kcnj8*)1Wco/0 involves: FVB/N MGI:6275066


Genotype
MGI:6275068
cn1
Allelic
Composition		 Tg(ACTB-EGFP,-Kcnj8*)1Wco/0
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: C3H * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTB-EGFP,-Kcnj8*)1Wco mutation (0 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood vessel physiology ( J:134852 )
• mice exhibit impaired coronary function, showing elevated basal coronary perfusion pressure of isolated hearts at a constant flow rate
• mice show elevated release of the vasoconstrictor endothelin-1 in the coronary effluent from hearts
• treatment with the ATP-sensitive K+ channel blocker glibenclamide fails to produce a vasoconstrictive response as in controls
• mice pretreated with the endothelin-1 receptor antagonist bosentan show normal coronary perfusion pressure
• mice exhibit normal response to coronary vasospasm induced with ergonovine

growth/size/body
growth/size/body region phenotype ( J:134852 )
N
• mice exhibit normal body weight and wet heart weight

mortality/aging
mortality/aging ( J:134852 )
N
• mice exhibit a normal lifespan




Genotype
MGI:6275067
cn2
Allelic
Composition		 Tg(ACTB-EGFP,-Kcnj8*)1Wco/0
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTB-EGFP,-Kcnj8*)1Wco mutation (0 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal myocardial fiber morphology ( J:134852 )
• isolated ventricular myocytes lack functional ATP-sensitive K+ channels

muscle
abnormal myocardial fiber morphology ( J:134852 )
• isolated ventricular myocytes lack functional ATP-sensitive K+ channels




Genotype
MGI:6275077
cn3
Allelic
Composition		 Tg(ACTB-EGFP,-Kcnj8*)1Wco/0
Tg(Myh11-icre/ERT2)1Soff/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTB-EGFP,-Kcnj8*)1Wco mutation (0 available)
Tg(Myh11-icre/ERT2)1Soff mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
hypertension ( J:202037 )
• mice exhibit an increase in blood pressure following tamoxifen treatment




Genotype
MGI:6275066
tg4
Allelic
Composition		 Tg(ACTB-EGFP,-Kcnj8*)1Wco/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:134852 )
• mice do not have any overt phenotype and have normal fertility




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory