Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm2(CAG-Nr5a1)Fjd}
• Allele Name: targeted mutation 2, Franco J DeMayo
• Allele ID: MGI:6275547
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm2(CAG-Nr5a1)Fjd/Gt(ROSA)26Sor^+ Pgr^tm2(cre)Lyd/Pgr^+	involves: 129S1/Sv * 129X1/SvJ	MGI:6275549

Genotype
MGI:6275549

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm2(CAG-Nr5a1)Fjd}/Gt(ROSA)26Sor⁺; Pgr^tm2(cre)Lyd/Pgr⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal decidualization ( J:269597 )

♀ • ovariectomized mice show an absent decidual response in uteri indicating that the endometrium is unable to undergo decidualization

endocrine/exocrine glands

abnormal endometrial gland morphology ( J:269597 )

♀ • abnormal morphology of uterine glands, including fluid-filled glands

abnormal endometrial gland development ( J:269597 )

♀ • marker analysis indicates that uterine glands are more differentiated, with a higher proportion of glandular to luminal cells

enlarged endometrial glands ( J:269597 )

♀ • uterine glands are twice the size in cell number as controls

immune system

uterus inflammation ( J:269597 )

♀ • mice show an increased presence of neutrophils in uteri

reproductive system

abnormal decidualization ( J:269597 )

♀ • ovariectomized mice show an absent decidual response in uteri indicating that the endometrium is unable to undergo decidualization

uterus inflammation ( J:269597 )

♀ • mice show an increased presence of neutrophils in uteri

abnormal uterus morphology ( J:269597 )

♀ • adult females in which endometriosis is induced by autotransplantation of uterine tissue to the mesenteric membrane show an increase in size of ectopic lesions; lesions show decreased epithelial cell proliferation, luminal epithelial cells that appear cuboidal instead of columnar, and most of the lesion volume is comprised of a large, fluid-filled central lumen

uterus cyst ( J:269597 )

♀ • females bred with wild-type males contain numerous cystic uterine glands

abnormal endometrium morphology ( J:269597 )

♀ • endometrial architecture is altered in bred females

abnormal endometrial gland morphology ( J:269597 )

♀ • abnormal morphology of uterine glands, including fluid-filled glands

abnormal endometrial gland development ( J:269597 )

♀ • marker analysis indicates that uterine glands are more differentiated, with a higher proportion of glandular to luminal cells

enlarged endometrial glands ( J:269597 )

♀ • uterine glands are twice the size in cell number as controls

enlarged uterine horn ( J:269597 )

♀ • females bred with wild-type males show enlarged and translucent uterine horns

female infertility ( J:269597 )

♀ • females bred with wild-type males do not reproduce

♀ • however, 3 week old females stimulated with gonadotrophins and mated with wild-type males exhibit a normal number of fertilized ova, normal progesterone and estradiol serum levels and normal uterine and ovarian estradiol levels, indicating normal ovarian and luteal function

growth/size/body

uterus cyst ( J:269597 )

♀ • females bred with wild-type males contain numerous cystic uterine glands