Phenotypes associated with this allele

• Allele Symbol: Cox7a2l^s
• Allele Name: short
• Allele ID: MGI:6276120
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cox7a2l^s/Cox7a2l^s	C57BL/6JCrl	MGI:6276127

Genotype
MGI:6276127

hm1

• Allelic Composition: Cox7a2l^s/Cox7a2l^s
• Genetic Background: C57BL/6JCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal respiratory electron transport chain ( J:199458 )

• mitochondria exhibit increased oxygen succinate or pyruvate and malate-driven rates of oxygen-consumption and ATP synthesis producing higher respiration rates compared with mitochondria expressing the long isoform of Cox7a2l^l

• mitochondria from mice fed ad libitum fail to exhibit an additive effect on maximum respiration stimulated by a combination of pyruvate and malate unlike in mitochondria from Hsd:ICR mice

• mitochondria from fasted mice fail to exhibit an increase in succinate respiration unlike in mitochondria from Hsd:ICR mice

• however, respiration rates driven by response to pyruvate, malate and succinate are normal