Phenotypes associated with this allele

• Allele Symbol: Amotl1^em1Rstot
• Allele Name: endonuclease-mediated mutation 1, Rolf Stottmann
• Allele ID: MGI:6276189
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Amotl1^em1Rstot/Amotl1^em1Rstot	involves: C57BL/6J * C57BL/6N	MGI:6295938
ht2	Amotl1^em1Rstot/Amotl1^+	involves: C57BL/6J * C57BL/6N	MGI:6295937

Genotype
MGI:6295938

hm1

• Allelic Composition: Amotl1^em1Rstot/Amotl1^em1Rstot
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:270029 )

• mice die within hours of birth

prenatal lethality, incomplete penetrance ( J:270029 )

• fewer than expected might are present at birth

• however, not mice are lost between E13.5 and E18.5

cardiovascular system

cardiovascular system phenotype ( J:270029 )

N • mice exhibit normal cardiac development

craniofacial

craniofacial phenotype ( J:270029 )

N • mice do not exhibit cleft palate

Genotype
MGI:6295937

ht2

• Allelic Composition: Amotl1^em1Rstot/Amotl1⁺
• Genetic Background: involves: C57BL/6J * C57BL/6N

mortality/aging

postnatal lethality, incomplete penetrance ( J:270029 )

• mice do not survive in Mendelian ratios at weaning