Phenotypes associated with this allele

• Allele Symbol: Rnpc3^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:6276236
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnpc3^tm1b(EUCOMM)Wtsi/Rnpc3^tm1b(EUCOMM)Wtsi	involves: C57BL/6N	MGI:6276270
hm2	Rnpc3^tm1b(EUCOMM)Wtsi/Rnpc3^tm1b(EUCOMM)Wtsi	involves: C57BL/6N * FVB	MGI:6276272
ht3	Rnpc3^tm1b(EUCOMM)Wtsi/Rnpc3^+	involves: C57BL/6N	MGI:6276269

Genotype
MGI:6276270

hm1

• Allelic Composition: Rnpc3^{tm1b(EUCOMM)Wtsi}/Rnpc3^{tm1b(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0441_1_B10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:267519 )

• all homozygotes die very early in development, prior to implantation

Genotype
MGI:6276272

hm2

• Allelic Composition: Rnpc3^{tm1b(EUCOMM)Wtsi}/Rnpc3^{tm1b(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N * FVB
• Cell Lines: EPD0441_1_B10

embryo

abnormal preimplantation embryo development ( J:267519 )

• in vitro analysis revealed that E3.5 blastocysts cultured for 24 hr fail to develop beyond the compacted cell morula stage and do not hatch from the zona pellucida

failure of blastocyst to hatch from the zona pellucida ( J:267519 )

embryonic growth arrest ( J:267519 )

• in vitro, E3.5 blastocysts cultured for 24 hr exhibit an arrested morula phenotype

Genotype
MGI:6276269

ht3

• Allelic Composition: Rnpc3^{tm1b(EUCOMM)Wtsi}/Rnpc3⁺
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0441_1_B10

normal phenotype

no abnormal phenotype detected ( J:267519 )

• adult heterozygotes are fertile, phenotypically normal, and exhibit a normal lifespan with no gross skeletal or growth defects or differences in pituitary gland weight relative to control littermates