Phenotypes associated with this allele

• Allele Symbol: Fgl1^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6276619
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgl1^tm1b(EUCOMM)Hmgu/Fgl1^tm1b(EUCOMM)Hmgu	involves: BALB/cJ * C57BL/6N	MGI:6276626

Genotype
MGI:6276626

hm1

• Allelic Composition: Fgl1^{tm1b(EUCOMM)Hmgu}/Fgl1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: involves: BALB/cJ * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:269578 )

N • mice have overall normal appearance and organ size

immune system

decreased B cell number ( J:269578 )

• decreases in two B cell subsets

increased central memory CD8 positive, alpha-beta T cell number ( J:269578 )

• small but significant increases in central memory-like CD8+ T-cell subsets (CD44+ CD62L+ Ly6C+ CD127^med Tbet+ Eomes+)

increased anti-double stranded DNA antibody level ( J:269578 )

♀ • at 14-16 months of age in 5/8 female mice but not in male mice

dermatitis ( J:269578 )

• up to 40% (8 out of 20 mice) develop spontaneous dermatitis at the age of 8 months or older with lymphocyte infiltration in the dermis

neoplasm

decreased tumor growth/size ( J:269578 )

• slower tumor growth following inoculation with syngeneic murine MC38 colon cancer cells compared to wild-type controls

• approximately 50% of mice are tumor free beyond 200 days after inoculation

integument

dermatitis ( J:269578 )

• up to 40% (8 out of 20 mice) develop spontaneous dermatitis at the age of 8 months or older with lymphocyte infiltration in the dermis

hematopoietic system

decreased B cell number ( J:269578 )

• decreases in two B cell subsets

increased central memory CD8 positive, alpha-beta T cell number ( J:269578 )

• small but significant increases in central memory-like CD8+ T-cell subsets (CD44+ CD62L+ Ly6C+ CD127^med Tbet+ Eomes+)