Analysis Tools
behavior/neurological
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• males exhibit lower sucrose preference, indicating depressive-like behavior
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• males exhibit lower sucrose preference, indicating depressive-like behavior
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• 2-month-old mice show a greater number of slips in the beam balance test; males lose their balance more times than wild-type mice and while females show more slips, significance is not reached
• however, time spent to cross the beam is not different, indicating that loss of balance is not attributed to deficits in muscle strength
• however, both male and female mice exhibit normal gait, hippocampal-dependent spatial memory, and normal behavior in the black and white test box, social interaction test, tail suspension test, and the open field
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• females, but not males, exhibit hyperactive behavior during the daytime, showing a consistent increase of back-and-forth movements across the box compared to wild-type females
• females maintain the hyperactivity during the nighttime
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• females show a higher number of daytime rearing
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• males, but not females, exhibit excessive nest-building activity, building better and larger nests and using more material compared to wild-type males
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growth/size/body
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IMPC - UCD
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IMPC - UCD
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hematopoietic system
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IMPC - UCD
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IMPC - UCD
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immune system
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IMPC - UCD
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IMPC - UCD
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IMPC - UCD
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integument
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IMPC - UCD
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liver/biliary system
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IMPC - UCD
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nervous system
| N |
• mice show normal brain weight and no brain abnormalities, including no phospho-tau deposits at 22 months of age
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renal/urinary system
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IMPC - UCD
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IMPC - UCD
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small kidney
(
J:211773
)
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IMPC - UCD
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vision/eye
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IMPC - UCD
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