Phenotypes associated with this allele

• Allele Symbol: Six1^em1(IMPC)Mbp
• Allele Name: endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:6276906
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Six1^em1(IMPC)Mbp/Six1^em1(IMPC)Mbp	C57BL/6N-Six1^em1(IMPC)Mbp/MbpMmucd	MGI:6408656
ht2	Six1^em1(IMPC)Mbp/Six1^+	C57BL/6N-Six1^em1(IMPC)Mbp/MbpMmucd	MGI:6461655

Genotype
MGI:6408656

hm1

• Allelic Composition: Six1^em1(IMPC)Mbp/Six1^em1(IMPC)Mbp
• Genetic Background: C57BL/6N-Six1^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Six1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:211773 )

IMPC - UCD

craniofacial

abnormal craniofacial morphology ( J:211773 )

IMPC - UCD

embryo

embryonic growth retardation ( J:211773 )

IMPC - UCD

abnormal placenta morphology ( J:211773 )

IMPC - UCD

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - UCD

homeostasis/metabolism

edema ( J:211773 )

IMPC - UCD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:6461655

ht2

• Allelic Composition: Six1^em1(IMPC)Mbp/Six1⁺
• Genetic Background: C57BL/6N-Six1^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Six1

cardiovascular system

abnormal blood vessel morphology ( J:211773 )

IMPC - UCD

abnormal placenta vasculature ( J:211773 )

IMPC - UCD

abnormal heart morphology ( J:211773 )

♂

IMPC - UCD

enlarged heart ( J:211773 )

♂

IMPC - UCD

decreased heart rate ( J:211773 )

♂

IMPC - UCD

prolonged RR interval ( J:211773 )

♂

IMPC - UCD

embryo

abnormal placenta morphology ( J:211773 )

IMPC - UCD

abnormal placenta vasculature ( J:211773 )

IMPC - UCD

growth/size/body

enlarged heart ( J:211773 )

♂

IMPC - UCD

enlarged kidney ( J:211773 )

♀

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

hematopoietic system

decreased leukocyte cell number ( J:211773 )

♀

IMPC - UCD

abnormal spleen morphology ( J:211773 )

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

small spleen ( J:211773 )

♀

IMPC - UCD

homeostasis/metabolism

decreased circulating calcium level ( J:211773 )

♂

IMPC - UCD

edema ( J:211773 )

IMPC - UCD

immune system

decreased leukocyte cell number ( J:211773 )

♀

IMPC - UCD

abnormal spleen morphology ( J:211773 )

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

small spleen ( J:211773 )

♀

IMPC - UCD

integument

abnormal skin morphology ( J:211773 )

♀

IMPC - UCD

nervous system

decreased prepulse inhibition ( J:211773 )

♂

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

IMPC - UCD

enlarged kidney ( J:211773 )

♀

IMPC - UCD

small kidney ( J:211773 )

♂

IMPC - UCD

reproductive system

abnormal uterus morphology ( J:211773 )

♀

IMPC - UCD

vision/eye

abnormal retina morphology ( J:211773 )

IMPC - UCD