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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nup155em1(IMPC)Mbp
endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
MGI:6276986
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nup155em1(IMPC)Mbp/Nup155em1(IMPC)Mbp C57BL/6NCrl-Nup155em1(IMPC)Mbp/Mmucd MGI:6408545
ht2
 		Nup155em1(IMPC)Mbp/Nup155+ C57BL/6NCrl-Nup155em1(IMPC)Mbp/Mmucd MGI:6461491


Genotype
MGI:6408545
hm1
Allelic
Composition		 Nup155em1(IMPC)Mbp/Nup155em1(IMPC)Mbp
Genetic
Background		 C57BL/6NCrl-Nup155em1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nup155em1(IMPC)Mbp mutation (1 available); any Nup155 mutation (94 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Nup155em1(IMPC)Mbp/Nup155em1(IMPC)Mbp mice exhibit embryonic lethality, with embryos recovered at E3.5 as early blastocysts but not at E7.5. Blastocysts grown in vitro do not hatch from the zona pellucida or form outgrowths.

embryo
failure of blastocyst to hatch from the zona pellucida ( J:279207 )
• in vitro, blastocysts fail to hatch from the zona pellucida after 3 days in culture

mortality/aging
embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )
• early blastocysts are present in approximate Mendelian ratios at E3.5 (33% versus expected 25%, n=24); no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system
failure of embryo implantation ( J:279207 )
• in vitro outgrowth assays show that blastocysts fail to hatch and do not form outgrowths after 3 days in culture




Genotype
MGI:6461491
ht2
Allelic
Composition		 Nup155em1(IMPC)Mbp/Nup155+
Genetic
Background		 C57BL/6NCrl-Nup155em1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nup155em1(IMPC)Mbp mutation (1 available); any Nup155 mutation (94 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
enlarged spleen ( J:211773 )
IMPC - UCD

hematopoietic system
enlarged spleen ( J:211773 )
IMPC - UCD

homeostasis/metabolism

immune system
enlarged spleen ( J:211773 )
IMPC - UCD




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory