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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nup155em1(IMPC)Mbp
endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
MGI:6276986
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nup155em1(IMPC)Mbp/Nup155em1(IMPC)Mbp C57BL/6NCrl-Nup155em1(IMPC)Mbp/Mmucd MGI:6408545
ht2
 		Nup155em1(IMPC)Mbp/Nup155+ C57BL/6NCrl-Nup155em1(IMPC)Mbp/Mmucd MGI:6461491


Genotype
MGI:6408545
hm1
Allelic
Composition		 Nup155em1(IMPC)Mbp/Nup155em1(IMPC)Mbp
Genetic
Background		 C57BL/6NCrl-Nup155em1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nup155em1(IMPC)Mbp mutation (1 available); any Nup155 mutation (94 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
failure of blastocyst to hatch from the zona pellucida ( J:279207 )
• in vitro, blastocysts fail to hatch from the zona pellucida after 3 days in culture

mortality/aging
embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )
• early blastocysts are present in higher than expected Mendelian ratios at E3.5 (33% versus 25%); no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system
failure of embryo implantation ( J:279207 )
• in vitro outgrowth assays show that blastocysts fail to hatch and form outgrowths after 3 days in culture




Genotype
MGI:6461491
ht2
Allelic
Composition		 Nup155em1(IMPC)Mbp/Nup155+
Genetic
Background		 C57BL/6NCrl-Nup155em1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nup155em1(IMPC)Mbp mutation (1 available); any Nup155 mutation (94 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
enlarged spleen ( J:211773 )
IMPC - UCD

hematopoietic system
enlarged spleen ( J:211773 )
IMPC - UCD

homeostasis/metabolism

immune system
enlarged spleen ( J:211773 )
IMPC - UCD




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/17/2024
MGI 6.24 		The Jackson Laboratory