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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Col27a1em1(IMPC)Mbp
endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
MGI:6277035
Summary 2 genotypes


Genotype
MGI:6408309
hm1
Allelic
Composition		 Col27a1em1(IMPC)Mbp/Col27a1em1(IMPC)Mbp
Genetic
Background		 C57BL/6N-Col27a1em1(IMPC)Mbp/MbpMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col27a1em1(IMPC)Mbp mutation (1 available); any Col27a1 mutation (79 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
hemorrhage ( J:211773 )
IMPC - UCD

craniofacial
cleft palate ( J:211773 )
IMPC - UCD

digestive/alimentary system
cleft palate ( J:211773 )
IMPC - UCD

embryo

growth/size/body
abnormal facial morphology ( J:211773 )
IMPC - UCD
cleft palate ( J:211773 )
IMPC - UCD
embryonic growth retardation ( J:211773 )
IMPC - UCD

homeostasis/metabolism
edema ( J:211773 )
IMPC - UCD

liver/biliary system
pale liver ( J:211773 )
IMPC - UCD

mortality/aging




Genotype
MGI:6461170
ht2
Allelic
Composition		 Col27a1em1(IMPC)Mbp/Col27a1+
Genetic
Background		 C57BL/6N-Col27a1em1(IMPC)Mbp/MbpMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col27a1em1(IMPC)Mbp mutation (1 available); any Col27a1 mutation (79 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system

embryo

growth/size/body
enlarged kidney ( J:211773 )
IMPC - UCD
enlarged spleen ( J:211773 )
IMPC - UCD

hematopoietic system
enlarged spleen ( J:211773 )
IMPC - UCD
small spleen ( J:211773 )
IMPC - UCD

homeostasis/metabolism
edema ( J:211773 )
IMPC - UCD

immune system
enlarged spleen ( J:211773 )
IMPC - UCD
small spleen ( J:211773 )
IMPC - UCD

renal/urinary system
enlarged kidney ( J:211773 )
IMPC - UCD

skeleton

vision/eye




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory