Phenotypes associated with this allele

• Allele Symbol: Atpsckmt^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6278547
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Atpsckmt^em1(IMPC)J/Atpsckmt^+	C57BL/6NJ-Atpsckmt^em1(IMPC)J	MGI:7612201

Genotype
MGI:7612201

ht1

• Allelic Composition: Atpsckmt^em1(IMPC)J/Atpsckmt⁺
• Genetic Background: C57BL/6NJ-Atpsckmt^em1(IMPC)J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:343227 )

N • non-primed mice show no significant differences in the course of carrageen-induced hyperalgesia relative to wild-type controls

increased mechanical nociceptive threshold ( J:343227 )

• carrageenan-primed mice show a significantly lower magnitude of persistent prostaglandin E2 (PGE2)-induced mechanical hyperalgesia than wild-type controls

abnormal nociception after inflammation ( J:343227 )

• after carrageenan-induced priming, the magnitude of persistent PGE2-induced mechanical and thermal hyperalgesia is significantly reduced in primed mice relative to wild-type controls

increased thermal nociceptive threshold ( J:343227 )

• carrageenan-primed mice show a significantly lower magnitude of persistent PGE2-induced thermal hyperalgesia than wild-type controls

nervous system

abnormal nervous system electrophysiology ( J:343227 )

• small dorsal root ganglia (DRG) neurons exhibit a small but significant decrease in the threshold of activation relative to wild-type DRG neurons

• however, resting membrane potential (RMP), rheobase, and relative refractory period are relatively unchanged

homeostasis/metabolism

abnormal calcium level ( J:343227 )

• DRG neurons exhibit slightly lower baseline intracellular Ca2+ levels than wild-type DRG neurons, as indicated by the amplitude of the F340/380 nm ratio

• however, capsaicin-evoked Ca2+ responses in cultured DRG neurons are normal