Phenotypes associated with this allele

• Allele Symbol: Tg(TBK1)#Andm
• Allele Name: transgene insertion, Michael G Anderson
• Allele ID: MGI:6278978
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(TBK1)#Andm/Tg(TBK1)#Andm	B6J.Cg-Tg(TBK1)#Andm	MGI:6278981
tg2	Tg(TBK1)#Andm/0	B6J.Cg-Tg(TBK1)#Andm	MGI:6278980

Genotype
MGI:6278981

tg1

• Allelic Composition: Tg(TBK1)#Andm/Tg(TBK1)#Andm
• Genetic Background: B6J.Cg-Tg(TBK1)#Andm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

retina ganglion cell degeneration ( J:241433 )

• 6 month old mice have 7.6% and 20% fewer retinal ganglion cells than hemizygous and wild-type mice, respectively

nervous system

retina ganglion cell degeneration ( J:241433 )

• 6 month old mice have 7.6% and 20% fewer retinal ganglion cells than hemizygous and wild-type mice, respectively

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
low tension glaucoma		DOID:13544		J:241433

Genotype
MGI:6278980

tg2

• Allelic Composition: Tg(TBK1)#Andm/0
• Genetic Background: B6J.Cg-Tg(TBK1)#Andm

vision/eye

retina ganglion cell degeneration ( J:241433 )

• mice exhibit progressive retinal ganglion cell loss with age, with a 9% decrease in ganglion cells at 3 months of age and 13% loss at 18 months of age

• however, mice have normal intraocular pressure at 5 weeks, 3 months, 7 months, 12 months, and 18 months of age

nervous system

retina ganglion cell degeneration ( J:241433 )

• mice exhibit progressive retinal ganglion cell loss with age, with a 9% decrease in ganglion cells at 3 months of age and 13% loss at 18 months of age

• however, mice have normal intraocular pressure at 5 weeks, 3 months, 7 months, 12 months, and 18 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
low tension glaucoma		DOID:13544		J:241433