Phenotypes associated with this allele

• Allele Symbol: Mettl21c^tm1.1Krug
• Allele Name: targeted mutation 1.1, Marcus Kruger
• Allele ID: MGI:6279318
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mettl21c^tm1.1Krug/Mettl21c^tm1.1Krug	involves: 129 * C57BL/6	MGI:6280420

Genotype
MGI:6280420

hm1

• Allelic Composition: Mettl21c^tm1.1Krug/Mettl21c^tm1.1Krug
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired exercise endurance ( J:270838 )

• mice show a >50% reduction in voluntary wheel running activity relative to wild-type controls, as determined by the sum of wheel rotations per night

• when forced to run on a treadmill at a constant velocity of 12 m/min, mice fatigue after ~20 min whereas wild-type controls are able to run constantly for at least 1 hr

muscle

abnormal muscle physiology ( J:270838 )

• mice exhibit loss of p97 K315 trimethylation in soleus slow type I fibers, leading to reduced p97 hexamer formation and decreased ATPase activity in soleus muscle lysates at 2, 4 and 8 months of age

muscle weakness ( J:270838 )

homeostasis/metabolism

impaired exercise endurance ( J:270838 )

• mice show a >50% reduction in voluntary wheel running activity relative to wild-type controls, as determined by the sum of wheel rotations per night

• when forced to run on a treadmill at a constant velocity of 12 m/min, mice fatigue after ~20 min whereas wild-type controls are able to run constantly for at least 1 hr

abnormal autophagy ( J:270838 )

• mice exhibit age-dependent accumulation of autophagic vacuoles in skeletal (soleus) muscle; in some cases, vesicular structures are found in direct proximity to mitochondria or protein aggregates

• following dissection of the sciatic nerve to induce muscle atrophy, mice show impaired induction of proteins involved in the autophagy-lysosome pathway

cellular

abnormal autophagy ( J:270838 )

• mice exhibit age-dependent accumulation of autophagic vacuoles in skeletal (soleus) muscle; in some cases, vesicular structures are found in direct proximity to mitochondria or protein aggregates

• following dissection of the sciatic nerve to induce muscle atrophy, mice show impaired induction of proteins involved in the autophagy-lysosome pathway