Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mrpl41em1(IMPC)Bay endonuclease-mediated mutation 1, Baylor College of Medicine MGI:6279932 |
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| Summary |
3 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mrpl41em1(IMPC)Bay/Mrpl41em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos at E7.5 show severe developmental delay, poorly organized extraembryonic tissues, and abnormal gastrulation.
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• although homozygous embryos are present in Mendelian ratios at E7.5 (30% versus expected 25%, n=10), none are recovered at E9.5
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• some Brachyury (T)-positive cells are present at E7.5
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• embryos show a severe developmental delay at E7.5
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• a small egg cylinder is observed at E7.5
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• some Brachyury (T)-positive cells are present at E7.5
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• extraembryonic tissues are poorly organized at E7.5
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• embryos show a severe developmental delay at E7.5
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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