Phenotypes associated with this allele

• Allele Symbol: Hip1^{tm5.2(HIP1)Tsr}
• Allele Name: targeted mutation 5.2, Theodora S Ross
• Allele ID: MGI:6280492
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hip1^tm5.2(HIP1)Tsr/Hip1^tm5.2(HIP1)Tsr	involves: C57BL/6 * SJL	MGI:6719501
cx2	Hip1^tm3Tsr/Hip1^tm5.2(HIP1)Tsr Hip1r^tm1Tsr/Hip1r^tm1Tsr	involves: 129X1/SvJ * C57BL/6 * SJL	MGI:6719556

Genotype
MGI:6719501

hm1

• Allelic Composition: Hip1^{tm5.2(HIP1)Tsr}/Hip1^{tm5.2(HIP1)Tsr}
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:267987 )

N • mice exhibit normal body weight up to 6 months of age

skeleton

skeleton phenotype ( J:267987 )

N • mice exhibit no kypholordotic spine up to 6 months of age, unlike Hip1^{tm5.1(HIP1)Tsr} homozygotes

N • only a slight kyphosis (but no lordosis) is observed, similar to wild-type controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:267987 )

N • mice show no significant alterations in phosphocholine levels or in any other choline-related metabolites in the liver

Genotype
MGI:6719556

cx2

• Allelic Composition: Hip1^tm3Tsr/Hip1^{tm5.2(HIP1)Tsr}; Hip1r^tm1Tsr/Hip1r^tm1Tsr
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

skeleton

skeleton phenotype ( J:267987 )

N • mice exhibit no kypholordotic spine, indicating rescue of the spinal phenotype by a single copy of human HIP1