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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gdpd3em1Tsr
endonuclease-mediated mutation 1,Theodora S Ross
MGI:6280493
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gdpd3em1Tsr/Gdpd3em1Tsr C57BL/6J-Gdpd3em1Tsr MGI:6719560
cx2
 		Gdpd3em1Tsr/Gdpd3em1Tsr
Hip1tm5.1(HIP1)Tsr/Hip1tm5.1(HIP1)Tsr 		involves: C57BL/6 * C57BL/6J MGI:6719561


Genotype
MGI:6719560
hm1
Allelic
Composition		 Gdpd3em1Tsr/Gdpd3em1Tsr
Genetic
Background		 C57BL/6J-Gdpd3em1Tsr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdpd3em1Tsr mutation (1 available); any Gdpd3 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:267987 )
N
• mice are viable, fertile and overtly normal with no detectable abnormalities up to 2 years of age; surprisingly, no major alterations are noted in phosphocholine- or homocysteine-related metabolites relative to wild-type controls




Genotype
MGI:6719561
cx2
Allelic
Composition		 Gdpd3em1Tsr/Gdpd3em1Tsr
Hip1tm5.1(HIP1)Tsr/Hip1tm5.1(HIP1)Tsr
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdpd3em1Tsr mutation (1 available); any Gdpd3 mutation (15 available)
Hip1tm5.1(HIP1)Tsr mutation (1 available); any Hip1 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
lordokyphosis ( J:267987 )
• mice exhibit a significantly earlier onset of kypholordosis with a smaller angle of the thoracic curvature noted at 10 months of age, indicating an accelerated and more severe kypholordotic phenotype relative to single Hip1tm5.1(HIP1)Tsr homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory